Mechanisms of muscle wasting in chronic kidney disease
نویسندگان
چکیده
منابع مشابه
Wasting in chronic kidney disease
Wasting/cachexia is prevalent among patients with chronic kidney disease (CKD). It is to be distinguished from malnutrition, which is defined as the consequence of insufficient food intake or an improper diet. Malnutrition is characterized by hunger, which is an adaptive response, whereas anorexia is prevalent in patients with wasting/cachexia. Energy expenditure decreases as a protective mecha...
متن کاملErratum to: Wasting in chronic kidney disease
In the original publication the initial letters for author T. Alp Ikizler had been printed in reverse order.
متن کاملProtein-Energy Wasting and Mortality in Chronic Kidney Disease
Protein-energy wasting (PEW) is common in patients with chronic kidney disease (CKD) and is associated with an increased death risk from cardiovascular diseases. However, while even minor renal dysfunction is an independent predictor of adverse cardiovascular prognosis, PEW becomes clinically manifest at an advanced stage, early before or during the dialytic stage. Mechanisms causing loss of mu...
متن کاملMelanocortin antagonism ameliorates muscle wasting and inflammation in chronic kidney disease.
Aberrant melanocortin signaling has been implicated in the pathogenesis of wasting in chronic kidney disease (CKD). Previously, we demonstrated that agouti-related peptide (AgRP), a melenocortin-4 receptor antagonist, reduced CKD-associated cachexia in CKD mice. Our previous studies with AgRP utilized dual energy X-ray (DXA) densitometry to assess the body composition in mice (Cheung W, Kuo HJ,...
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ژورنال
عنوان ژورنال: Nature Reviews Nephrology
سال: 2014
ISSN: 1759-5061,1759-507X
DOI: 10.1038/nrneph.2014.112